KRT75

Across TCGA pan-cancer cohorts, KRT75 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KRT75 data layer compared with 18 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KRT75 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KRT75 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where KRT75 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.485	0.246	.003	47	view →
LSCC	OS	Median	III,IV	0.986	0.509	.001	22	view →
HNSC	OS	Quartile	All	0.928	0.738	.005	15	view →
UCEC	DFS	Median	II,III,IV	1.000	0.521	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KRT75–PDAC (DFS)

Open the PDAC breakdown →