KRT75

Across TCGA cell cohorts, KRT75 mutation is significantly associated with the RNA expression of many other genes, with 58 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT75-associated genes across cancer lineages are LORICRIN, OCSTAMP, and FREM3. Each is linked with KRT75 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT75-to-partner and partner-to-KRT75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LORICRIN grouped by KRT75-low versus KRT75-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT75→partner) and Y-score (partner→KRT75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	LORICRIN →	+0.053	+4.584	<.001	.002	3	2
OESOPHAGUS	OCSTAMP →	+0.010	+3.273	.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	FREM3 →	+0.039	+2.777	.006	.008	3	2
URINARY_TRACT	MAGEB4 →	+0.005	+4.087	<.001	.009	3	1
URINARY_TRACT	CST11 →	+0.057	+4.087	<.001	.009	3	1
URINARY_TRACT	DMRTB1 →	+0.014	+4.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

LORICRIN by KRT75 expression — URINARY_TRACT

Explore this box plot interactively →