KRT74

Across TCGA pan-cancer cohorts, KRT74 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KRT74 data layer compared with 14 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher KRT74 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KRT74 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

BLCA, STAD, and LUAD are the cancer types where KRT74 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.169	0.620	<.001	48	view →
STAD	OS	Median	All	0.202	0.589	<.001	36	view →
LUAD	OS	Median	All	0.339	0.700	.036	6	view →
LUSC	DFS	Median	All	0.136	0.791	.005	3	view →
SKCM	OS	Median	All	0.966	0.867	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

KRT74–BLCA (OS)

Open the BLCA breakdown →