KRT74

Across TCGA patient cohorts, KRT74 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT74-associated genes across cancer lineages are c-Met_pY1235, HER3_pY1289, and mTOR_pS2448. Each is linked with KRT74 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT74-to-partner and partner-to-KRT74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by KRT74-low versus KRT74-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT74→partner) and Y-score (partner→KRT74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Met_pY1235 →	+0.095	+1.749	.011	.049	3	2
UCEC	HER3_pY1289 →	+0.084	+3.189	.031	.010	3	2
UCEC	mTOR_pS2448 →	-0.190	-3.156	.004	.018	3	2
UCEC	Bak →	+0.315	+2.000	.005	.032	3	2
UCEC	Cyclin-E2 →	+0.202	+3.321	.007	.009	3	2
LUAD	4E-BP1_pT70 →	+0.270	+2.824	.014	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

c-Met_pY1235 by KRT74 expression — SKCM

Explore this box plot interactively →