KRT74

Across TCGA cell cohorts, KRT74 RNA expression is significantly associated with the go_rna of many other GO terms, with 814 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible KRT74-associated GO terms across cancer lineages are Aerobic respiration, Regulation of cap-independent translational initiation, and Positive regulation of cap-independent translational initiation. Each is linked with KRT74 in more than 4 cancer types. Because this analysis shows association rather than direction, both KRT74-to-partner and partner-to-KRT74 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aerobic respiration grouped by KRT74-low versus KRT74-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT74→partner) and Y-score (partner→KRT74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Aerobic respiration →	+0.080	+0.260	.001	<.001	3	5
OESOPHAGUS	Regulation of cap-independent translational initiation →	+0.153	+0.585	<.001	.004	3	5
OESOPHAGUS	Positive regulation of cap-independent translational initiation →	+0.153	+0.585	<.001	.004	3	5
LUNG_NSCLC_LUSC	Pericardium morphogenesis →	+1.250	+0.432	.001	.003	3	5
OVARY	Alternative mRNA splicing, via spliceosome →	+0.097	+0.026	<.001	.004	3	5
LUNG_NSCLC_LUSC	L-histidine transport →	+0.143	+0.366	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 814 associations by consensus.

Aerobic respiration by KRT74 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →