Across TCGA patient cohorts, KRT73 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT73-associated genes across cancer lineages are mTOR_pS2448, Annexin-1, and Chk2. Each is linked with KRT73 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT73-to-partner and partner-to-KRT73 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT73→partner) and Y-score (partner→KRT73) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.133	-2.446	.017	.018	3	2
UCEC	Annexin-1 →	+0.719	+2.662	<.001	<.001	3	2
UCEC	Chk2 →	-0.217	-2.000	.013	.030	3	2
SKCM	JNK2 →	+0.207	+2.132	.019	.010	3	1
SKCM	mTOR →	-0.234	-2.807	.025	.003	3	1
SKCM	Rab25 →	-0.244	-3.296	.026	.009	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

KRT73 survival (RNA) · tumor vs normal (RNA) · all KRT73 data types