KRT7

Across TCGA patient cohorts, KRT7 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT7-associated genes across cancer lineages are eEF2, Snail, and Bak. Each is linked with KRT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT7-to-partner and partner-to-KRT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by KRT7-low versus KRT7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT7→partner) and Y-score (partner→KRT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.449	+3.169	.022	.020	3	2
SKCM	Snail →	-0.232	-3.446	.003	.005	3	1
SKCM	Bak →	+0.255	+3.334	.012	.005	2	2
UCEC	Ku80 →	+0.274	+2.817	.035	.036	3	1
UCEC	SLC1A5 →	-0.495	-3.162	.034	.019	2	2
UCEC	STAT3_pY705 →	-0.494	-3.169	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

eEF2 by KRT7 expression — UCEC

Explore this box plot interactively →