Across TCGA pan-cancer cohorts, KRT5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated KRT5 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KRT5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRT5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and COAD show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where KRT5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.646	0.956	.005	18	view →
HNSC	DFS	Tertile	All	1.000	0.936	.020	15	view →
PDAC	DFS	Median	II,III,IV	0.316	0.449	.035	7	view →
COAD	DFS	Median	IV	1.000	0.565	.049	6	view →
CCRCC	OS	Median	III,IV	1.000	0.654	.008	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: KRT5 tumor-vs-normal RNA expression · all KRT5 data types