Across TCGA patient cohorts, KRT5 protein abundance is significantly associated with the RNA expression of many other genes, with 14,318 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible KRT5-associated genes across cancer lineages are ZNF750, KRT17, and FGFBP1. Each is linked with KRT5 in more than 5 cancer types. Because this analysis shows association rather than direction, both KRT5-to-partner and partner-to-KRT5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT5→partner) and Y-score (partner→KRT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF750 →	+1.026	+0.826	<.001	<.001	3	6
HNSC	KRT17 →	+2.615	+1.136	<.001	<.001	3	6
LSCC	FGFBP1 →	+2.128	+1.108	<.001	<.001	3	6
LSCC	TMTC1 →	+1.088	+0.982	.001	.003	3	5
LSCC	DENND2C →	+1.141	+0.855	<.001	<.001	3	5
BRCA	SNAI2 →	+1.253	+1.351	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,318 associations by consensus.

Exploration

KRT5 survival (RNA) · tumor vs normal (RNA) · all KRT5 data types