Across TCGA patient cohorts, KRT5 mutation is significantly associated with the RNA expression of many other genes, with 1,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT5-associated genes across cancer lineages are MIR4774, RNU6-340P, and RNU4-75P. Each is linked with KRT5 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT5-to-partner and partner-to-KRT5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT5→partner) and Y-score (partner→KRT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	3
HNSC	RNU6-340P →	+0.177	+4.614	<.001	.004	3	2
HNSC	RNU4-75P →	+0.136	+4.614	<.001	.004	3	2
CESC	RPL37P24 →	+0.119	+4.816	<.001	.003	3	2
UCEC	SRCIN1 →	-0.609	-2.494	.001	.001	3	2
BLCA	MIR1289-2 →	+0.235	+4.618	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,271 associations by consensus.

Exploration

KRT5 survival (RNA) · tumor vs normal (RNA) · all KRT5 data types