KRT43P

Across TCGA pan-cancer cohorts, KRT43P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of KRT43P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KRT43P RNA is repressed in tumor relative to normal tissue. In most cancer types KRT43P is over-expressed in tumor, although a few such as HNSC and BRCA show the opposite, repressed pattern.

HNSC, COAD, and LUSC are the cancer types where KRT43P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT43P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.222	.008	4	view →
COAD	All	II,III,IV	+0.237	.029	2	view →
LUSC	Female	All	+0.152	.018	2	view →
BRCA	All	III,IV	−0.017	.024	2	view →
ESCA	Female	All	−0.170	.001	1	view →
KIRP	All	All	+0.017	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

KRT43P–HNSC

Open the HNSC breakdown →