Across TCGA pan-cancer cohorts, KRT40 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KRT40 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KRT40 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated KRT40 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

SKCM, PRAD, and ESCA are the cancer types where KRT40 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	1.000	0.664	.008	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: KRT40 tumor-vs-normal RNA expression · all KRT40 data types