Across TCGA patient cohorts, KRT40 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT40-associated genes across cancer lineages are MEK1, Cyclin-B1, and p27_pT157. Each is linked with KRT40 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT40-to-partner and partner-to-KRT40 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT40→partner) and Y-score (partner→KRT40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.548	+3.906	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.762	+3.584	<.001	.002	3	2
SKCM	p27_pT157 →	+0.239	+2.883	<.001	.031	3	1
UCEC	EGFR_pY1068 →	-0.252	-2.321	.012	.033	3	1
UCEC	A-Raf_pS299 →	-0.192	-2.584	<.001	.010	3	1
UCEC	ERK2 →	+0.187	+2.321	.015	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Exploration

KRT40 survival (RNA) · tumor vs normal (RNA) · all KRT40 data types