Across TCGA cell cohorts, KRT40 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KRT40-associated genes across cancer lineages are KCNA5, PRY2, and PRAMEF10. Each is linked with KRT40 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT40-to-partner and partner-to-KRT40 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT40→partner) and Y-score (partner→KRT40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KCNA5 →	+0.122	+5.369	<.001	.004	3	1
SOFT_TISSUE	PRY2 →	+0.026	+5.977	<.001	.001	3	1
SOFT_TISSUE	PRAMEF10 →	+0.012	+4.930	.008	.008	3	1
BLOOD_Leukemia	RIT2 →	+0.028	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	LYZL4 →	+0.049	+4.152	.005	.009	3	1
BLOOD_Leukemia	OR4K2 →	+0.031	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

KRT40 survival (RNA) · tumor vs normal (RNA) · all KRT40 data types