KRT4

Across TCGA pan-cancer cohorts, KRT4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KRT4 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KRT4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRT4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where KRT4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.720	0.987	.001	31	view →
HNSC	DFS	Quartile	III,IV	0.891	0.455	<.001	17	view →
PDAC	OS	Median	III,IV	0.313	0.585	.010	5	view →
UCEC	OS	Tertile	All	1.000	0.920	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KRT4–LUAD (DFS)

Open the LUAD breakdown →