KRT4

Across TCGA patient cohorts, KRT4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,935 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible KRT4-associated GO terms across cancer lineages are Establishment of skin barrier, Epidermal cell differentiation, and Regulation of epidermis development. Each is linked with KRT4 in more than 14 cancer types. Because this analysis shows association rather than direction, both KRT4-to-partner and partner-to-KRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of skin barrier grouped by KRT4-low versus KRT4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT4→partner) and Y-score (partner→KRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Establishment of skin barrier →	+0.051	+2.867	<.001	<.001	3	15
ESCA	Epidermal cell differentiation →	+0.057	+4.263	<.001	<.001	3	15
SCLC	Regulation of epidermis development →	+0.072	+0.907	.001	<.001	2	14
ESCA	Skin epidermis development →	+0.048	+3.751	<.001	<.001	3	12
STAD	Positive regulation of epidermis development →	+0.053	+1.279	<.001	<.001	2	13
MESO	Regulation of antimicrobial humoral response →	+0.072	+1.467	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,935 associations by consensus.

Establishment of skin barrier by KRT4 expression — ESCA

Explore this box plot interactively →