KRT4

Across TCGA patient cohorts, KRT4 mutation is significantly associated with the RNA expression of many other genes, with 2,299 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT4-associated genes across cancer lineages are ATP5MGP6, FAM136A, and OR10D1P. Each is linked with KRT4 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT4-to-partner and partner-to-KRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5MGP6 grouped by KRT4-low versus KRT4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT4→partner) and Y-score (partner→KRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ATP5MGP6 →	+0.216	+3.653	.003	.009	3	3
UCEC	FAM136A →	+0.371	+2.711	.003	.003	3	3
BLCA	OR10D1P →	+0.068	+3.241	.007	.009	3	3
UCEC	PSMA4 →	+0.430	+2.732	.001	.003	3	3
UCEC	MYL12BP1 →	+0.428	+2.354	<.001	.003	3	2
UCEC	AURKB →	+0.645	+3.470	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,299 associations by consensus.

ATP5MGP6 by KRT4 expression — CESC

Explore this box plot interactively →