KRT4

Across TCGA patient cohorts, KRT4 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT4-associated genes across cancer lineages are EGFR_pY1173, FoxM1, and 14-3-3_beta. Each is linked with KRT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT4-to-partner and partner-to-KRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by KRT4-low versus KRT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT4→partner) and Y-score (partner→KRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.068	+1.512	.035	.035	3	2
UCEC	FoxM1 →	+0.261	+1.906	.012	.016	3	2
UCEC	14-3-3_beta →	-0.080	-2.295	.048	.033	3	1
UCEC	MSH6 →	-0.319	-1.874	.016	.049	3	1
UCEC	p21 →	+0.176	+2.459	.022	.019	3	1
UCEC	Rab25 →	-0.445	-3.169	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1173 by KRT4 expression — UCEC

Explore this box plot interactively →