KRT4

Across TCGA cell cohorts, KRT4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,597 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible KRT4-associated GO terms across cancer lineages are Positive regulation of axon guidance, Regulation of synapse structural plasticity, and Cerebral cortex radially oriented cell migration. Each is linked with KRT4 in more than 8 cancer types. Because this analysis shows association rather than direction, both KRT4-to-partner and partner-to-KRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of axon guidance grouped by KRT4-low versus KRT4-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT4→partner) and Y-score (partner→KRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of axon guidance →	-1.272	-3.800	<.001	<.001	3	9
URINARY_TRACT	Regulation of synapse structural plasticity →	-1.550	-3.559	<.001	<.001	3	8
BONE	Cerebral cortex radially oriented cell migration →	+0.111	+0.115	.001	.001	3	7
OESOPHAGUS	Positive regulation of synapse maturation →	+0.334	+4.949	<.001	.005	3	7
URINARY_TRACT	Regulation of mucus secretion →	+1.300	+3.671	<.001	<.001	3	7
BREAST	AV node cell action potential →	+0.988	+3.619	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,597 associations by consensus.

Positive regulation of axon guidance by KRT4 expression — URINARY_TRACT

Explore this box plot interactively →