KRT4

Across TCGA cell cohorts, KRT4 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT4-associated genes across cancer lineages are SNU13, ATP8B4, and OR10W1. Each is linked with KRT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT4-to-partner and partner-to-KRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNU13 grouped by KRT4-low versus KRT4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT4→partner) and Y-score (partner→KRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SNU13 →	+0.562	+3.067	.001	.009	3	1
LARGE_INTESTINE	ATP8B4 →	+0.288	+3.131	.002	.008	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1
LARGE_INTESTINE	ACSM6 →	+0.021	+3.906	<.001	<.001	3	1
LARGE_INTESTINE	MROH2A →	+0.329	+3.302	.004	.008	3	1
SKIN	OLFM3 →	+0.226	+2.672	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SNU13 by KRT4 expression — LARGE_INTESTINE

Explore this box plot interactively →