Across TCGA pan-cancer cohorts, KRT39 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KRT39’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where KRT39 RNA is repressed in tumor relative to normal tissue. In most cancer types KRT39 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.
KICH, LUAD, and LUSC are the cancer types where KRT39 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT39 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.