KRT38

Across TCGA patient cohorts, KRT38 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT38-associated genes across cancer lineages are Notch1, PDCD4, and STAT3_pY705. Each is linked with KRT38 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT38-to-partner and partner-to-KRT38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KRT38-low versus KRT38-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT38→partner) and Y-score (partner→KRT38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.177	+3.183	.002	.009	3	3
UCEC	PDCD4 →	-0.699	-2.321	<.001	.006	3	2
UCEC	STAT3_pY705 →	-0.313	-2.000	.003	.029	3	2
SKCM	LKB1 →	+0.099	+2.497	.028	.009	3	2
SKCM	Annexin_VII →	+0.136	+2.000	.019	.009	3	2
LUAD	RAD51 →	+0.261	+2.824	.012	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Notch1 by KRT38 expression — UCEC

Explore this box plot interactively →