KRT38

Across TCGA cell cohorts, KRT38 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT38-associated genes across cancer lineages are RSPH6A, IL20, and DNASE1L3. Each is linked with KRT38 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT38-to-partner and partner-to-KRT38 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPH6A grouped by KRT38-low versus KRT38-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT38→partner) and Y-score (partner→KRT38) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSPH6A →	+0.120	+3.466	<.001	.005	3	1
LARGE_INTESTINE	IL20 →	+0.170	+3.662	.001	.009	3	1
LARGE_INTESTINE	DNASE1L3 →	+0.077	+3.977	.002	<.001	3	1
LARGE_INTESTINE	SLC35G3 →	+0.006	+2.882	<.001	.005	3	1
LARGE_INTESTINE	PENK →	+0.388	+3.451	.002	.008	3	1
LARGE_INTESTINE	TRDN →	+0.032	+2.791	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

RSPH6A by KRT38 expression — LARGE_INTESTINE

Explore this box plot interactively →