Across TCGA patient cohorts, KRT35 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT35-associated genes across cancer lineages are VHL, Caspase-8, and JNK2. Each is linked with KRT35 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT35-to-partner and partner-to-KRT35 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT35→partner) and Y-score (partner→KRT35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.027	-3.459	.001	.005	3	2
UCEC	Caspase-8 →	-0.244	-2.973	.037	.035	3	2
UCEC	JNK2 →	+0.263	+2.584	.004	.011	3	1
UCEC	MEK1 →	+0.439	+2.584	.010	.011	3	1
UCEC	MSH2 →	-0.338	-3.433	.001	.005	3	1
UCEC	N-Ras →	-0.142	-2.571	.010	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

KRT35 survival (RNA) · tumor vs normal (RNA) · all KRT35 data types