KRT33B

Across TCGA pan-cancer cohorts, KRT33B Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KRT33B data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KRT33B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRT33B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, LUAD, and UCEC are the cancer types where KRT33B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
LUAD	DFS	Median	II,III,IV	0.168	0.655	.005	18	view →
UCEC	DFS	Median	II,III,IV	1.000	0.487	.036	8	view →
ESCA	OS	Median	II,III,IV	0.226	0.686	.013	6	view →
LIHC	OS	Median	All	0.098	0.774	.001	6	view →
SKCM	OS	Median	III,IV	0.212	0.729	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KRT33B–ACC (DFS)

Open the ACC breakdown →