KRT33B

Across TCGA patient cohorts, KRT33B mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT33B-associated genes across cancer lineages are MEK1, eEF2, and JNK2. Each is linked with KRT33B in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT33B-to-partner and partner-to-KRT33B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by KRT33B-low versus KRT33B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT33B→partner) and Y-score (partner→KRT33B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.431	+3.000	.001	<.001	3	3
UCEC	eEF2 →	+0.296	+2.321	.021	.033	3	2
UCEC	JNK2 →	+0.274	+2.331	<.001	.003	3	2
UCEC	PDCD4 →	-0.530	-2.459	.001	.018	3	2
UCEC	STAT3_pY705 →	-0.270	-1.700	.004	.040	3	2
UCEC	TFRC →	+0.425	+2.321	.026	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

MEK1 by KRT33B expression — UCEC

Explore this box plot interactively →