KRT33B

Across TCGA cell cohorts, KRT33B mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible KRT33B-associated genes across cancer lineages are RIT2, KRTAP15-1, and LY6G6D. Each is linked with KRT33B in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT33B-to-partner and partner-to-KRT33B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIT2 grouped by KRT33B-low versus KRT33B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT33B→partner) and Y-score (partner→KRT33B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RIT2 →	+0.020	+4.022	<.001	.006	3	1
SKIN	KRTAP15-1 →	+0.025	+4.022	<.001	.006	3	1
SKIN	LY6G6D →	+0.083	+3.688	.001	.002	3	1
LUNG_SCLC	OR1M1 →	+0.016	+5.643	<.001	.002	3	1
OVARY	ANKRD66 →	+0.023	+5.196	<.001	.005	3	1
SKIN	LMNTD1 →	+0.219	+3.443	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

RIT2 by KRT33B expression — SKIN

Explore this box plot interactively →