KRT31

Across TCGA patient cohorts, KRT31 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT31-associated genes across cancer lineages are TFRC, GAPDH, and Caspase-7-cleavedD198. Each is linked with KRT31 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT31-to-partner and partner-to-KRT31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by KRT31-low versus KRT31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT31→partner) and Y-score (partner→KRT31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.550	+2.459	.012	.019	3	3
SKCM	GAPDH →	+0.762	+3.169	.003	.017	3	2
COAD	Caspase-7-cleavedD198 →	+0.990	+2.178	.007	.035	3	2
UCEC	mTOR_pS2448 →	-0.211	-3.680	<.001	.001	3	2
UCEC	Notch1 →	+0.222	+3.472	<.001	.002	3	2
UCEC	ATM →	-0.564	-3.000	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

TFRC by KRT31 expression — UCEC

Explore this box plot interactively →