KRT31

Across TCGA cell cohorts, KRT31 RNA expression is significantly associated with the go_rna of many other GO terms, with 541 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible KRT31-associated GO terms across cancer lineages are Regulation of intrinsic apoptotic signaling pathway, Regulation of purine nucleotide biosynthetic process, and Regulation of nucleotide biosynthetic process. Each is linked with KRT31 in more than 3 cancer types. Because this analysis shows association rather than direction, both KRT31-to-partner and partner-to-KRT31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of intrinsic apoptotic signaling pathway grouped by KRT31-low versus KRT31-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT31→partner) and Y-score (partner→KRT31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of intrinsic apoptotic signaling pathway →	+0.063	+0.683	<.001	.005	3	4
CNS	Regulation of purine nucleotide biosynthetic process →	+0.061	+0.013	.004	.009	3	4
CNS	Regulation of nucleotide biosynthetic process →	+0.061	+0.013	.004	.009	3	4
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitochondrial fusion →	+0.087	+0.539	<.001	.004	3	4
LUNG_NSCLC_LUAD	Negative regulation of ubiquitin-dependent protein catabolic process →	+0.042	+0.011	.001	.009	3	3
LUNG_NSCLC_LUAD	Regulation of CD40 signaling pathway →	+0.167	+0.009	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 541 associations by consensus.

Regulation of intrinsic apoptotic signaling pathway by KRT31 expression — LARGE_INTESTINE

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