Across TCGA pan-cancer cohorts, KRT3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated KRT3 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KRT3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated KRT3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC and HNSC are the cancer types where KRT3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.696	0.366	.007	9	view →
HNSC	OS	Quartile	All	0.924	0.772	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KRT3 tumor-vs-normal RNA expression · all KRT3 data types