Across TCGA pan-cancer cohorts, KRT25 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KRT25 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher KRT25 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated KRT25 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, LIHC, and HNSC are the cancer types where KRT25 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.650	.012	28	view →
LIHC	OS	Median	All	0.507	0.777	<.001	10	view →
HNSC	OS	Median	III,IV	0.198	0.745	.003	9	view →
LUSC	DFS	Median	II,III,IV	1.000	0.377	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: KRT25 tumor-vs-normal RNA expression · all KRT25 data types