Across TCGA patient cohorts, KRT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,005 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible KRT2-associated GO terms across cancer lineages are Regulation of cysteine-type endopeptidase activity, Regulation of production of molecular mediator of immune response, and Negative regulation of leukocyte cell-cell adhesion. Each is linked with KRT2 in more than 15 cancer types. Because this analysis shows association rather than direction, both KRT2-to-partner and partner-to-KRT2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT2→partner) and Y-score (partner→KRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PAAD	Regulation of cysteine-type endopeptidase activity →	+0.033	+0.154	<.001	.001	3	15
KIRC	Regulation of production of molecular mediator of immune response →	+0.020	+0.138	<.001	<.001	3	15
UVM	Negative regulation of leukocyte cell-cell adhesion →	+0.030	+0.010	.001	.007	1	16
TGCT	Interferon-beta production →	+0.046	+0.136	<.001	.007	1	16
TGCT	Positive regulation of lymphocyte differentiation →	+0.038	+0.212	<.001	.004	3	14
PAAD	Positive regulation of pattern recognition receptor signaling pathway →	+0.037	+0.111	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,005 associations by consensus.

Exploration

KRT2 survival (RNA) · tumor vs normal (RNA) · all KRT2 data types