KRT2

Across TCGA patient cohorts, KRT2 mutation is significantly associated with the RNA expression of many other genes, with 1,735 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT2-associated genes across cancer lineages are RNA5SP369, FCF1P6, and DUXAP3. Each is linked with KRT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT2-to-partner and partner-to-KRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP369 grouped by KRT2-low versus KRT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT2→partner) and Y-score (partner→KRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP369 →	+0.324	+2.023	<.001	.002	3	3
BRCA	FCF1P6 →	+0.232	+3.915	<.001	.002	3	3
UCEC	DUXAP3 →	+0.120	+1.770	<.001	.005	3	3
UCEC	MARCKSL1P2 →	+0.181	+2.039	<.001	.005	3	3
UCEC	RNU6-927P →	+0.223	+2.505	<.001	.001	3	3
UCEC	ATP2A1-AS1 →	+0.930	+2.023	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,735 associations by consensus.

RNA5SP369 by KRT2 expression — UCEC

Explore this box plot interactively →