KRT2

Across TCGA patient cohorts, KRT2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT2-associated genes across cancer lineages are Notch1, Akt_pS473, and Akt_pT308. Each is linked with KRT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT2-to-partner and partner-to-KRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by KRT2-low versus KRT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT2→partner) and Y-score (partner→KRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.146	+2.472	.006	.010	3	2
UCEC	Akt_pS473 →	+0.696	+1.678	.011	.023	3	2
UCEC	Akt_pT308 →	+0.538	+3.321	.026	.009	3	2
UCEC	S6_pS240_S244 →	+0.394	+2.183	.011	.033	3	2
UCEC	Tuberin_pT1462 →	+0.338	+1.916	<.001	.009	3	2
UCEC	VHL →	-1.029	-1.678	<.001	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Notch1 by KRT2 expression — UCEC

Explore this box plot interactively →