KRT2

Across TCGA cell cohorts, KRT2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,613 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible KRT2-associated genes across cancer lineages are TOP1MT, BOP1, and SMS. Each is linked with KRT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both KRT2-to-partner and partner-to-KRT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KRT2 versus TOP1MT in LUNG_SCLC, with a Pearson correlation of -0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT2→partner) and Y-score (partner→KRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TOP1MT →	-1.429	-0.870	.001	.005	3	4
LIVER	BOP1 →	-0.725	-1.688	.002	.003	3	4
UPPER_AERODIGESTIVE_TRACT	SMS →	-1.081	-1.158	.007	.007	3	4
LUNG_NSCLC_LUAD	TMC5 →	-1.882	-0.938	.006	.003	3	3
UPPER_AERODIGESTIVE_TRACT	CCND1 →	-1.610	-1.396	<.001	.001	3	3
LUNG_NSCLC_LUAD	RAB17 →	-1.813	-0.781	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,613 associations by consensus.

KRT2 vs TOP1MT — LUNG_SCLC

Explore this scatter interactively →