KRT2

Across TCGA cell cohorts, KRT2 mutation is significantly associated with the RNA expression of many other genes, with 318 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT2-associated genes across cancer lineages are VWC2L, OR13D1, and DBX2. Each is linked with KRT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT2-to-partner and partner-to-KRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWC2L grouped by KRT2-low versus KRT2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT2→partner) and Y-score (partner→KRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VWC2L →	+0.016	+4.339	<.001	.002	3	2
BLOOD_Leukemia	OR13D1 →	+0.064	+3.744	.001	.009	3	2
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	1
BLOOD_Leukemia	ASZ1 →	+0.105	+4.567	.001	.001	3	1
BLOOD_Leukemia	CALHM4 →	+0.030	+4.269	<.001	.002	3	1
BLOOD_Leukemia	SSX3 →	+1.287	+4.824	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 318 associations by consensus.

VWC2L by KRT2 expression — BLOOD_Leukemia

Explore this box plot interactively →