KRT19

Across TCGA pan-cancer cohorts, KRT19 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated KRT19 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher KRT19 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KRT19 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

PDAC, COAD, and HNSC are the cancer types where KRT19 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.200	0.669	.001	32	view →
COAD	DFS	Quartile	III,IV	1.000	0.827	.033	30	view →
HNSC	OS	Median	All	0.617	0.813	.006	7	view →
LSCC	OS	Tertile	II,III,IV	0.735	0.910	.028	7	view →
LUAD	OS	Tertile	II,III,IV	0.281	0.717	.013	4	view →
UCEC	DFS	Quartile	All	1.000	0.878	.035	2	view →
GBM	OS	Quartile	All	0.745	1.000	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

KRT19–PDAC (OS)

Open the PDAC breakdown →