KRT18P8

Across TCGA pan-cancer cohorts, KRT18P8 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KRT18P8 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KRT18P8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRT18P8 expression acts as an unfavorable survival marker, although some lineages such as THCA and KIRP show a favorable association.

SKCM, PAAD, and UCEC are the cancer types where KRT18P8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	III,IV	0.443	0.673	<.001	55	view →
PAAD	DFS	Quartile	All	0.231	0.518	<.001	49	view →
UCEC	DFS	Tertile	All	0.869	0.936	.008	42	view →
THCA	OS	Quartile	II,III,IV	1.000	0.765	.001	36	view →
ESCA	OS	Tertile	All	0.436	1.000	.008	28	view →
KIRC	DFS	Quartile	All	0.710	0.863	.018	18	view →
GBM	OS	Tertile	All	0.152	0.445	<.001	18	view →
PRAD	DFS	Tertile	All	0.703	0.896	.005	14	view →
DLBC	DFS	Quartile	II,III,IV	0.205	0.767	.024	11	view →
TGCT	DFS	Quartile	All	0.642	0.905	.005	10	view →
OV	OS	Quartile	II,III,IV	0.641	0.737	.035	10	view →
LUAD	DFS	Median	II,III,IV	0.625	0.731	.016	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

KRT18P8–SKCM (DFS)

Open the SKCM breakdown →