KRT18P53

Across TCGA pan-cancer cohorts, KRT18P53 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated KRT18P53 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher KRT18P53 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRT18P53 expression acts as an unfavorable survival marker, although some lineages such as LIHC and UCEC show a favorable association.

MESO, KICH, and BLCA are the cancer types where KRT18P53 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	II,III,IV	0.372	0.599	.005	90	view →
KICH	OS	Tertile	All	0.082	0.877	<.001	81	view →
BLCA	OS	Tertile	All	0.191	0.612	<.001	45	view →
BRCA	OS	Tertile	IV	0.233	0.755	.038	36	view →
THYM	DFS	Tertile	All	0.174	0.759	.028	27	view →
OV	DFS	Tertile	All	0.326	0.397	.022	24	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	18	view →
GBM	OS	Tertile	All	0.166	0.414	.024	18	view →
LIHC	OS	Tertile	All	0.958	0.764	.018	9	view →
LGG	OS	Tertile	All	0.307	0.799	.015	9	view →
STAD	DFS	Median	IV	0.157	0.566	.003	9	view →
KIRC	DFS	Tertile	All	0.589	0.805	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

KRT18P53–MESO (OS)

Open the MESO breakdown →