KRT18P52

Across TCGA pan-cancer cohorts, KRT18P52 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KRT18P52’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KRT18P52 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT18P52 is over-expressed in tumor.

HNSC, COAD, and KIRP are the cancer types where KRT18P52 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT18P52 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.059	<.001	7	view →
COAD	Female	II,III,IV	+0.292	.001	6	view →
KIRP	All	IV	+0.205	.006	6	view →
STAD	All	All	+0.231	.001	4	view →
THCA	All	II,III,IV	+0.141	<.001	4	view →
BRCA	All	All	+0.103	.002	4	view →
LUAD	All	All	+0.070	.017	4	view →
BLCA	Female	III,IV	+0.151	.020	2	view →
UCEC	All	All	+0.142	.025	2	view →
PRAD	All	All	+0.114	<.001	2	view →
LIHC	All	II,III,IV	+0.050	.033	1	view →
KIRC	Male	All	+0.034	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KRT18P52–HNSC

Open the HNSC breakdown →