Across TCGA pan-cancer cohorts, KRT18P19 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of KRT18P19’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where KRT18P19 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRT18P19 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.
STAD, KIRP, and LUAD are the cancer types where KRT18P19 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRT18P19 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.