KRT18

Across TCGA pan-cancer cohorts, KRT18 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated KRT18 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KRT18 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated KRT18 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

LUAD, HNSC, and COAD are the cancer types where KRT18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.748	0.994	.002	39	view →
HNSC	OS	Quartile	All	0.530	0.824	.003	34	view →
COAD	DFS	Median	III,IV	1.000	0.897	.044	12	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.458	.021	12	view →
PDAC	OS	Tertile	II,III,IV	0.253	0.507	.014	12	view →
GBM	DFS	Median	All	0.489	0.256	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

KRT18–LUAD (DFS)

Open the LUAD breakdown →