KRT17

Across TCGA patient cohorts, KRT17 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT17-associated genes across cancer lineages are STAT3_pY705, VHL, and Heregulin. Each is linked with KRT17 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT17-to-partner and partner-to-KRT17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by KRT17-low versus KRT17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT17→partner) and Y-score (partner→KRT17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.313	-1.874	.001	.049	3	3
UCEC	VHL →	-0.501	-2.000	.049	.030	3	2
UCEC	Heregulin →	-0.102	-1.415	.028	.046	3	1
UCEC	JNK2 →	+0.307	+2.662	<.001	<.001	3	1
UCEC	Ku80 →	+0.284	+2.183	.001	.001	3	1
UCEC	MYH11 →	+0.859	+2.321	.046	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

STAT3_pY705 by KRT17 expression — UCEC

Explore this box plot interactively →