Across TCGA patient cohorts, KRT16 mutation is significantly associated with the RNA expression of many other genes, with 3,603 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT16-associated genes across cancer lineages are TPM3P9, BUB3, and SLC35B1. Each is linked with KRT16 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT16-to-partner and partner-to-KRT16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT16→partner) and Y-score (partner→KRT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TPM3P9 →	+0.526	+2.748	<.001	.003	3	3
UCEC	BUB3 →	+0.487	+3.534	<.001	.002	3	3
UCEC	SLC35B1 →	+0.419	+2.684	<.001	<.001	3	3
UCEC	RRM2 →	+0.789	+2.815	.002	.001	3	3
GBM	RNU2-62P →	+0.239	+4.969	<.001	.009	3	2
GBM	PSMA6P3 →	+0.357	+5.149	.003	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,603 associations by consensus.

Exploration

KRT16 survival (RNA) · tumor vs normal (RNA) · all KRT16 data types