Across TCGA patient cohorts, KRT16 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT16-associated genes across cancer lineages are PEA-15_pS116, eIF4E, and GATA6. Each is linked with KRT16 in more than 2 cancer types. Because this analysis shows association rather than direction, both KRT16-to-partner and partner-to-KRT16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT16→partner) and Y-score (partner→KRT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.480	+2.222	.001	.011	3	2
UCEC	eIF4E →	+0.192	+2.222	.032	.011	3	2
UCEC	GATA6 →	-0.225	-2.899	<.001	.001	3	2
UCEC	PRDX1 →	+0.222	+2.459	.011	.019	3	2
UCEC	Caspase-8 →	-0.283	-3.558	.008	.002	3	2
SKCM	PI3K-p85 →	+0.186	+3.169	.018	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

KRT16 survival (RNA) · tumor vs normal (RNA) · all KRT16 data types