Across TCGA cell cohorts, KRT16 mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KRT16-associated genes across cancer lineages are UTF1, OR4A47, and OR2AG1. Each is linked with KRT16 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT16-to-partner and partner-to-KRT16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT16→partner) and Y-score (partner→KRT16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UTF1 →	+0.015	+3.217	<.001	.006	3	2
LARGE_INTESTINE	OR4A47 →	+0.012	+3.700	<.001	.009	3	2
BREAST	OR2AG1 →	+0.014	+4.426	<.001	<.001	3	2
BLOOD_Myeloma	STOML3 →	+0.006	+4.807	<.001	.006	3	1
URINARY_TRACT	LIM2 →	+0.035	+4.087	<.001	.009	3	1
URINARY_TRACT	TXNDC8 →	+0.010	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

KRT16 survival (RNA) · tumor vs normal (RNA) · all KRT16 data types