Across TCGA patient cohorts, KRT14 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT14-associated genes across cancer lineages are EGFR_pY1068, GSK-3a-b_pS21_S9, and ACC1. Each is linked with KRT14 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT14-to-partner and partner-to-KRT14 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT14→partner) and Y-score (partner→KRT14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.242	-1.906	.016	.016	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.366	+1.906	.033	.016	3	1
UCEC	ACC1 →	+0.379	+2.584	.009	.010	3	1
UCEC	INPP4B →	-0.308	-3.321	.018	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.198	-3.321	.003	.010	3	1
UCEC	JNK2 →	+0.292	+2.710	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

KRT14 survival (RNA) · tumor vs normal (RNA) · all KRT14 data types