Across TCGA patient cohorts, KRT12 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT12-associated genes across cancer lineages are Rab25, ASNS, and PRDX1. Each is linked with KRT12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT12-to-partner and partner-to-KRT12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT12→partner) and Y-score (partner→KRT12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.250	-1.415	.044	.046	3	2
UCEC	ASNS →	+0.440	+2.222	.001	.010	3	2
SKCM	PRDX1 →	+0.387	+2.000	.003	.031	3	1
UCEC	eIF4E →	+0.241	+3.321	.002	<.001	3	1
UCEC	FASN →	+0.338	+2.999	.022	.035	3	1
UCEC	FoxM1 →	+0.205	+1.874	.034	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

KRT12 survival (RNA) · tumor vs normal (RNA) · all KRT12 data types