Across TCGA cell cohorts, KRT12 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KRT12-associated genes across cancer lineages are ADAM30, OR7D4, and MAGEB3. Each is linked with KRT12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT12-to-partner and partner-to-KRT12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT12→partner) and Y-score (partner→KRT12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ADAM30 →	+0.029	+4.882	<.001	.001	3	1
SOFT_TISSUE	OR7D4 →	+0.022	+4.977	<.001	.002	3	1
SOFT_TISSUE	MAGEB3 →	+0.049	+4.222	<.001	.007	3	1
SKIN	RS1 →	+0.041	+2.994	<.001	.006	3	1
SKIN	GNGT2 →	+0.259	+3.544	<.001	.006	3	1
SKIN	FGA →	+0.062	+3.442	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

KRT12 survival (RNA) · tumor vs normal (RNA) · all KRT12 data types