Across TCGA patient cohorts, KRT10 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRT10-associated genes across cancer lineages are ETS-1, HSP70, and p38-MAPK. Each is linked with KRT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRT10-to-partner and partner-to-KRT10 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRT10→partner) and Y-score (partner→KRT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ETS-1 →	+0.295	+3.000	.033	.034	3	1
SKCM	HSP70 →	-0.641	-3.000	.014	.034	3	1
SKCM	p38-MAPK →	+0.170	+2.321	.047	.035	3	1
SKCM	AMPK_alpha →	+0.310	+3.000	<.001	.034	3	1
SKCM	Rb_pS807_S811 →	-0.472	-2.321	.028	.035	3	1
SKCM	Rictor_pT1135 →	-0.159	-3.144	.038	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

KRT10 survival (RNA) · tumor vs normal (RNA) · all KRT10 data types